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Cardiac Fibrosis and Heart Failure: Cause or Effect? (Advances in Biochemistry in Health and Disease #13) (Paperback)

Cardiac Fibrosis and Heart Failure: Cause or Effect? (Advances in Biochemistry in Health and Disease #13) By Ian M. C. Dixon (Editor), Jeffrey T. Wigle (Editor) Cover Image
By Ian M. C. Dixon (Editor), Jeffrey T. Wigle (Editor)
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Description


1. Fibrosis and Heart Failure - Cause or Effect?
Ian M.C. Dixon, Ryan H. Cunnington, S.G. Rattan and J.T. Wigle

2. Fibroblast Activation in the Infarcted Myocardium
Amit Saxena and Nicholas Frangogiannis

3. Mechanical and Matrix Regulation of Valvular Fibrosis
Mark C. Blaser and Craig A. Simmons

4. Bone Marrow-Derived Progenitor Cells, micro-RNA, and Fibrosis
Alison L. Muller and Darren H. Freed

5. The Stressful Life of Cardiac Myofibroblasts
Elena Zimina and Boris Hinz

6. Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies Aldosteronism

R. Justin McCullough, Yao Sun, Kevin P. Newman, Kodangudi B. Ramanathan, Ramareddy V. Guntaka and Karl T. Weber

7. Embryological origin of valve progenitor cells
Michel Puc at & Thomas Moore-Morris

8. Diverse cellular origins of cardiac fibroblasts
Fahmida Jahan and Jeffrey T. Wigle


9. Non-Canonical Regulation of TGF-β1 Signaling: A Role for Ski/Sno and YAP/TAZ
Mathew R. Zeglinski, Natalie Landry and Ian M.C. Dixon

10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart
Christina Pagiatakis and John C. McDermott,

11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis.
Patricia Roche and Michael P. Czubryt


12. Remodelling of the cardiac extracellular matrix: Role of collagen degradation and accumulation in pathogenesis of heart failure
Abhijit Takawale, Mengcheng Shen, Dong Fan, Zamaneh Kassiri

13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix Remodelling
Fouad A. Zouein, Ashley Decoux1, Yuan Tian1, Jared White, Yu-Fang Jin and and Merry L. Lindsey

14. Collagen processing and its role in Fibrosis
Christopher A. McCulloch and Nuno M. Coelho

15. Mechanisms of Cardiac Fibrosis
Keith Dadson, Vera Kovacevic and Gary Sweeney

16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and Myocytes
K. A. MacCannell, L. Chilton, G. L. Smith, and W. R. Giles

17. Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives
Holly Mewhort and Paul Fedak

18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure
Nirmal Parajuli, Tharmarajan Ramprasath, Pavel Zhabyeyev,
Vaibhav B. Patel and Gavin Y. Oudit

19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart
Hailey J. Jansen and Robert A. Rose

20. Cardiac Tissue Engineering for the Treatment of Heart Failure Post-Infarction
Jacqueline S. Wendel, Robert. T Tranquillo

21. Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves
Meghana R.K. Helder and Robert D. Simari

About the Author


Dr. Jeffrey Wigle is an Associate Professor at the University of Manitoba, Winnipeg, Canada. His research focuses on the transcriptional pathways involved in regulating the growth and development of the cardiovascular system. He has characterized a number of transcription factors that are critical for the development of the lymphatic vasculature and the phenoconversion of fibroblasts to myofibroblasts. He is currently studying the transcriptional feedback loops that determine the fibroblastic phenotype.Dr. Ian M.C. Dixon is a Professor of Physiology and Pathophysiology at the University of Manitoba, Winnipeg, Canada. His research addresses heart failure following myocardial infarction and the contributing role of dysfunctional extracellular matrix in these hearts. He is also interested in mechanisms of fibroblast phenotype regulation, cardiac fibroblast SMAD protein signaling as well as other signaling proteins that may oppose the fibrogenic influence of TGF-b1 in health and disease. He has been engaged over the past 24 years in multidisciplinary research in cardiovascular matrix biology.


Product Details
ISBN: 9783319379951
ISBN-10: 331937995X
Publisher: Springer
Publication Date: October 22nd, 2016
Pages: 436
Language: English
Series: Advances in Biochemistry in Health and Disease